Where does Alpa-2-Macroglobulin (A2M) come from?
A2M is found in high concentrations in your blood. The A2M found naturally in your blood inhibits all three proteins that break down your cartilage, causing Osteoarthritis (OA). The protective characteristics of A2M designate this vital protein as the human body's own defense against Osteoarthritis (OA). Similar to your body increasing white blood cells in response to infection, A2M is unregulated in response to a cartilage injury. A significant research study out of Brown University, in collaboration with the National Institute of Health, demonstrated that although concentration of intra-articular A2M is insufficient for joint protection, a supplemental intra-articular injection of A2M provides chondral protection in post-traumatic OA by stopping the progression of Osteoarthritis (OA).